Evidence, connected.

A working library of papers, official research records, and technical frameworks—summarized with limits visible and relationships mapped.

Read past the headline.

SourcePrefer the paper, PubMed record, DOI, university archive, or official standard.

FindingRecord what the study actually reports—not the broadest interpretation.

LimitsKeep sample, method, model, and translation constraints attached.

ConnectionsMap shared mechanisms and questions without implying agreement.

Research index

Each note links to an official source and separates reported results from Spirit Labs’ interpretation.

RN–0012025
Primary research

Adversarial testing of global neuronal workspace and integrated information theories

A preregistered, theory-neutral collaboration directly tested divergent predictions from IIT and GNWT using fMRI, MEG, and intracranial EEG in 256 participants.

ConsciousnessIITGNWTNeuroimaging
Open note ↗
RN–0022014
Primary research

Enhanced repertoire of brain dynamical states during the psychedelic experience

Functional neuroimaging in a small psilocybin study found increased diversity in transient connectivity states relative to placebo.

PsychedelicsPsilocybinEntropyfMRI
Open note ↗
RN–0032026
Primary research

Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy

An independent cohort analysis compared multiple entropy metrics across 121 pre- and post-psilocybin fMRI scans and found that the measures do not capture one interchangeable construct.

PsychedelicsMethodsEntropyReplication
Open note ↗
RN–0042022
Primary research

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

Researchers computationally screened a bespoke virtual library of 75 million tetrahydropyridine-containing compounds against the serotonin 5-HT2A receptor.

Drug discovery5-HT2AComputationPsychedelics
Open note ↗
RN–0052023
Primary research

Soft, miniaturized, wireless olfactory interface for virtual reality

The paper reports skin-interfaced, wirelessly programmable arrays of miniature odor generators designed for olfactory VR applications.

SmellVRWearablesSensory interfaces
Open note ↗
RN–0062024
Primary research

Ketamine can produce oscillatory dynamics by engaging mechanisms dependent on NMDA-receptor kinetics

A computational model links ketamine’s actions at NMDA receptors to changes in cellular dynamics and brain rhythms observed across different dosing regimes.

KetamineComputational neuroscienceNMDABrain rhythms
Open note ↗
RN–0072025
Clinical technical report

A streaming brain-to-voice neuroprosthesis to restore naturalistic communication

High-density cortical recordings and streaming neural decoding produced personalized synthesized speech in 80-millisecond increments for a participant with severe paralysis.

BCISpeechNeuroprostheticsClinical research
Open note ↗
RN–0082014
Theory review

Consciousness in the universe: a review of the Orch OR theory

Hameroff and Penrose review their proposal that orchestrated quantum processes in neuronal microtubules terminate through objective reduction and correspond to conscious moments.

Orch ORQuantum consciousnessMicrotubulesTheory
Open note ↗
RN–0092008
Technical roadmap

Whole Brain Emulation: A Roadmap

A technology-assessment roadmap breaks whole-brain emulation into challenges involving scanning, interpretation, modeling, implementation, and validation.

Whole-brain emulationMind uploadingIdentityRoadmap
Open note ↗