Researchers computationally screened a bespoke virtual library of 75 million tetrahydropyridine-containing compounds against the serotonin 5-HT2A receptor.
REPORTED FINDINGS
01Selected molecules were synthesized and experimentally evaluated.
02Two candidates produced antidepressant-like behavioral effects in mice without the standard mouse head-twitch proxy.
03The work demonstrates a receptor-informed computational discovery pipeline.
LIMITS / CAUTION
Mouse behavioral proxies do not establish antidepressant efficacy, subjective effects, or safety in humans.