A computational model links ketamine’s actions at NMDA receptors to changes in cellular dynamics and brain rhythms observed across different dosing regimes.
REPORTED FINDINGS
01The model connects molecular kinetics with network-level oscillatory dynamics.
02It offers mechanistic hypotheses for altered arousal and therapeutic effects.
03The work demonstrates translation across molecular, cellular, and systems scales.
LIMITS / CAUTION
A mechanistic model can organize evidence and generate predictions but does not by itself establish the complete causal pathway in humans.