Enhanced repertoire of brain dynamical states during the psychedelic experience

Tagliazucchi, E. et al. Human Brain Mapping 35, 5442–5456 (2014).

Functional neuroimaging in a small psilocybin study found increased diversity in transient connectivity states relative to placebo.

REPORTED FINDINGS

01Connectivity-state entropy increased after psilocybin.

02Some connectivity patterns appeared only after psilocybin in the analyzed data.

03The work connected macroscopic brain dynamics with reports of unconstrained, hyper-associative experience.

LIMITS / CAUTION

Small sample, acute pharmacological context, and analysis-dependent entropy measures limit broad conclusions about consciousness or therapeutic effects.