An independent cohort analysis compared multiple entropy metrics across 121 pre- and post-psilocybin fMRI scans and found that the measures do not capture one interchangeable construct.
REPORTED FINDINGS
01Several spatial and state-switching metrics increased with psilocybin.
02Eight of fourteen evaluated metrics did not show consistent significant effects.
03Different entropy measures had limited correlations with one another.
LIMITS / CAUTION
The paper addresses acute fMRI signal properties; “entropy” should not be treated as a unitary measure of expanded consciousness.